Gene Synthesis Market

The global Gene Synthesis Market is valued at USD 2.81 Billion in 2024 and is projected to reach a value of USD 13.64 Billion by 2035 at a CAGR (Compound Annual Growth Rate) of 15.45% between 2025 and 2035.

Key highlights of Gene Synthesis Market

• North America dominated the market in 2024, obtaining the largest revenue share of 37.7%.
• The Linear double-standard gene fragments(dsDNA) segment dominated the Gene Synthesis market with the largest market share of 69.8% in 2024.
• The Polymerase Chain Reaction (PCR) segment dominated the Gene Synthesis market with the largest market share of 58.8% in 2024.
• The Academic and Research Institute segment dominated the Gene Synthesis market with the largest market share of 44.03% in 2024.
• The Research and development segment dominated the Gene Synthesis market with the largest market share of 57.7% in 2024.
• The Gene Synthesis Services segment dominated the Gene Synthesis market with the largest market share of 66.2% in 2024.
• The Cell and gene therapies segment dominated the Gene Synthesis market with the largest market share of 43.8% in 2024.
• The companies in the market are working to innovate products with more efficiency, low-cost, and easily adaptable which are further estimated to enhance the growth of the market.

Gene Synthesis Market: Regional Overview

North America Dominated Sales with a 37.7% share in 2024. The North America gene synthesis market including the United States, Canada, and Mexico. Factors such as advancements in biotechnology, strong presence of pharmaceutical and biotechnology companies, research and development initiatives, and favorable regulatory frameworks contribute to the growth and development of the gene synthesis market in North America. For instance, in April 2022, Ansa Biotechnologies, a start -up based in California, is making strides towards introducing a customizable DNA synthesis service. The companys efforts are driven by the development of a novel synthesis method that aims to enhance DNA synthesis technologies.

U.S. Gene Synthesis Market Overview

The gene synthesis market in the United States is experiencing significant growth, driven by advancements in biotechnology, genomics, and synthetic biology. Gene synthesis involves the artificial production of DNA or RNA sequences, enabling the creation of custom-designed genes for various applications. The United States has a robust biotechnology and pharmaceutical industry, which contributes to the demand for gene synthesis services. Companies in these sectors utilize gene synthesis to develop novel therapeutics, vaccines, and diagnostic tools. Gene synthesis also plays a crucial role in research and development activities, allowing scientists to study and manipulate genetic sequences for a better understanding of diseases and biological processes. For instance, in May 2023, GenScript announced the launch of GenTitan, the worlds first commercial semiconductor platform for DNA synthesis. This advanced platform powers GenScripts latest gene fragment synthesis service. With the introduction of GenTitan, GenScript has achieved the highest acceptance rate for complex sequences and is now able to provide custom synthetic genes at a remarkably low price compared to industry standards.

The global Gene Synthesis market can be categorized as Product, Technology, End User, Application, Services, Final Usage, and Region.

Gene Synthesis Market: Product Overview

In 2024, the Linear double-standard gene fragments(dsDNA) segment dominated the market, with the largest share accounting for 69.8% of the overall market. The Gene Synthesis market, segmented by the Propulsion, includes Short mers single-stranded oligos (ssDNA), Linear double-stranded gene fragments(dsDNA), and Circular clonal plasmids. Linear dsDNA fragments are longer DNA molecules synthesized as double-stranded DNA. These fragments are typically used in gene assembly processes, where multiple linear fragments are combined to construct a complete gene or genetic construct. For instance, in September 2022, GenScript USA Inc., a provider of life science research tools and services, launched GenWand Double-Stranded DNA (dsDNA) service. This service is specifically tailored for the production of CRISPR knock-in homology-directed repair (HDR) templates in T cell engineering applications.

Gene Synthesis Market: Technology Overview

In 2024, the Polymerase Chain Reaction (PCR) segment dominated the market, with the largest share accounting for 58.8% of the overall market. The Gene Synthesis market, segmented by the Technology, includes Polymerase chain reaction (PCR), Oligonucleotide synthesis, Gene Assembly, Site-directed mutagenesis. PCR is a technique used to amplify a specific DNA sequence. In gene synthesis, PCR can be utilized to amplify and replicate DNA fragments before they are assembled into a complete gene. PCR is known for its high accuracy and precision in amplifying specific DNA sequences. This makes it a crucial technology in gene synthesis, where the precise replication and amplification of DNA fragments are essential for creating synthetic genes. The increasing demand for synthetic genes in various fields, such as biotechnology, pharmaceuticals, agriculture, and research, drives the need for efficient and reliable gene synthesis methods. PCRs ability to accurately amplify DNA fragments aligns well with this demand, contributing to its popularity in the gene synthesis market.

Gene Synthesis Market: End User Overview

In 2024, the Academic and research institutes segment dominated the market, with the largest share accounting for 44.03% of the overall market. The Gene Synthesis market, segmented by the End User, includes Academic and research institutes, pharmaceuticals companies, biotechnologies companies, and contract research organization. Academic institutions and research organizations are significant end-users of gene synthesis services. They utilize gene synthesis for various research projects, studying gene function, genetic engineering, drug discovery, and advancing knowledge in fields like molecular biology, genetics, and biotechnology. For instance, in June 2023, Eurofins Genomics Blue Heron, a provider of DNA synthesis, sequencing services, and gene synthesis, launched its IVT mRNA Synthesis Service. This service aims to revolutionize gene expression research by providing a solution to the existing challenges.

Gene Synthesis Market: Application Overview

In 2024, the Research & development segment dominated the market, with the largest share accounting for 57.7% of the overall market. The Gene Synthesis market, segmented by the Application, includes Research & Development, Diagnostics, Therapeutics, and Others. Gene synthesis plays a critical role in various research and development activities across multiple disciplines. It enables scientists to study gene function, create genetic constructs for experimental purposes, develop new technologies, and gain insights into complex biological systems. For instance, In August 2022, GenScript USA Inc., a renowned provider of life science research tools and services, unveiled a new messenger RNA (mRNA) synthesis service for biopharmaceutical research and development teams. This service is available for research use only (RUO) and pre-clinical purposes.

Gene Synthesis Market: Services Overview

In 2024, the Gene synthesis services segment dominated the market, with the largest share accounting for 66.2% of the overall market. The Gene Synthesis market, segmented by the Services, includes Gene synthesis services, GMP Gene Synthesis, Gene fragments service, and Others. Gene synthesis services involves the synthesis of complete genes based on specific customer requirements. It includes the design, assembly, and delivery of synthetic genes with desired sequences and modifications. Several companies are using various strategies to further drive demand for the gene synthesis service across the market. For instance, in November 2021, GenScript USA Inc., opened a 50,000-square-foot facility for highly automated gene synthesis and plasmid preparation services near its U.S. headquarters in Piscataway.

Gene Synthesis Market: Final Usage Overview

In 2024, the Cell and gene therapies segment dominated the market, with the largest share accounting for 43.8% of the overall market. The Gene Synthesis market, segmented by the Final Usage, includes Nucleic acid based vaccine, cell and gene therapies, protein/mAb Engineering, Genome programming. Gene synthesis enables the production of therapeutic genes or gene-editing tools required for these advanced therapies. Cell and gene therapies offer potential treatments for various genetic disorders by introducing functional genes or correcting genetic mutations. Gene synthesis plays a vital role in producing therapeutic genes or gene-editing tools required for these therapies. The ability to address genetic disorders, advancements in precision medicine, the prevalence of chronic diseases, gene editing technologies, regulatory support, research and clinical trials, and industry collaborations contribute to the increasing demand for gene synthesis services in the development of cell and gene therapies.

Key Trends

• In 2024, the Linear double-stranded gene fragments (dsDNA) category dominate the market and is projected to witness significant growth in the coming years.
• In 2024, the Polymerase Chain Reaction (PCR) had a major share. Moreover, pharmaceuticals category to witness the fastest growth over the forecast period.
• In 2024, North America category had a major share in the market.

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Market Dynamics

Growing Demand for Customized DNA Sequences

Customized DNA sequences are tailored to specific research, diagnostic, and therapeutic needs, and gene synthesis plays a vital role in delivering these sequences efficiently and accurately. In various fields such as biomedical research, drug development, agriculture, and personalized medicine, researchers and industry professionals require precise and tailor -made DNA sequences. Gene synthesis enables the design and production of custom DNA constructs that meet these specific requirements. The advent of precision medicine, which aims to provide personalized treatments based on an individuals genetic makeup, further fuels the demand for customized DNA sequences. Gene synthesis is crucial in producing DNA constructs for genetic testing, diagnostics, and the development of targeted therapeutics. Custom DNA sequences are designed and synthesized to identify genetic variants, detect biomarkers, and create models that mimic genetic disorders for drug screening and development. In addition, the agricultural biotechnology sector relies on gene synthesis to engineer crops with enhanced traits, such as disease resistance and improved yield. Customized DNA sequences are designed and synthesized to introduce specific genetic modifications into crop plants, contributing to the development of sustainable agriculture. The demand for customized DNA sequences drives the need for efficient and reliable gene synthesis services. Gene synthesis providers leverage advancements in DNA synthesis technologies to deliver high-quality and cost effective customized DNA constructs to researchers, clinicians, and industry professionals.

Increasing demand for precision medicine

Precision medicine aims to provide personalized and targeted medical treatments based on an individuals genetic makeup, environmental factors, and lifestyle. This approach requires the utilization of customized DNA sequences, and gene synthesis plays a crucial role in fulfilling this demand. Gene synthesis enables the production of tailored DNA constructs that are designed to match an individuals specific genetic information. Gene synthesis allows researchers and clinicians to obtain precise DNA constructs that are essential for identifying genetic variations, studying gene expression patterns, developing personalized treatment strategies, and creating disease models. As precision medicine continues to gain prominence and expand its applications, the demand for gene synthesis services is expected to rise. Gene synthesis providers are vital in meeting this demand by offering fast, accurate, and cost - effective synthesis of custom DNA constructs. Their ability to produce customized DNA sequences that match the unique genetic profiles of patients drives advancements in precision medicine, ultimately improving patient outcomes and personalized treatment approaches.

Competitive Landscape

The global market is a competitive and fragmented market due to the high presence of players in the market. Only a few companies account for a major market share, and hence, the degree of competition among the suppliers is high as the players in the market are active at global, regional, and country level. Also, the increasing rivalry between the players to obtain the majority of the market share for global has played a major role in intensifying the level of competition. The Major Companies are THERMO FISHER SCIENTIFIC INC., GENSCRIPT, INTEGRATED DNA TECHNOLOGIES INC., ORIGENE TECHNOLOGIES INC., BIOMATIK, TWIST BIOSCIENCE, BROOKS AUTOMATION INC., BOSTER BIOLOGICAL TECHNOLOGY, PROTEOGENIX INC., PROMAB BIOTECHNOLOGIES INC., MERCK KGAA, EUROFINS GENOMICS, BIO BASIC INC., Gene Universal Inc.

Recent Developments

• In February 2023, GenScript launched new GenTitan Gene Fragments Synthesis service. The service uses GenScripts proprietary MSC technology to offer a more affordable and efficient way to synthesize gene fragments
• In February 2023, Integrated DNA Technologies (IDT) announced the launch of its new MiniGene Synthetic Genes service. The service offers a convenient way to obtain synthetic genes that are less than 5000 bp in length.